whats the back bone of a application enginer for dmg mori

In fact, epidemiological study in the Chinese population suggested that the prevalence of knee OA had reached 18% in the country ( Wang et al., 2018). With the improvement of human life expectancy and the development of social aging process, the incidence of OA will greatly increase during the following decades. This is consistent with a more recent study in young adults which identified a risk difference of 8.1 for knee OA, between individuals with and without knee injury at 19 years of follow-up ( Snoeker et al., 2020). Acute knee injury has also been shown to be a risk factor for OA, with individuals with cartilage damage 7.4 times more likely to develop the disease ( Wilder et al., 2002). In fact, retrospective studies with arthroscopic examinations reveal the presence of chondral lesions in nearly 60% of the patients ( Chubinskaya et al., 2015). Osteoarthritis refers to exposure of subchondral bone to the joint space, which causes inflammation that may be accompanied by osteophyte development, severe pain, and progressive loss of joint function. Therefore, without sufficient and potent treatment, cartilage damage can easily lead to progressive tissue deterioration, debilitating joint pain, dysfunction, and eventually the degenerative disease, osteoarthritis (OA) ( Borrelli et al., 2019). Moreover, mature AC has a limited ability to self-renew and repair as it is avascular, lacks innervation and has a low cell-density ( Chiang and Jiang, 2009).

However, the constant mechanical stresses that are experienced by the AC makes it vulnerable to wear, tears, and sports injuries. Its main function is to allow for an almost friction-less movement of the joints, and facilitate the transmission of loads whilst protecting the subchondral bone. Articular cartilage (AC) is a highly specialized connective tissue that covers the surfaces of bones in a synovial joint.

Whats the back bone of a application enginer for dmg mori